Clinical outcome after SVR: Veterans Affairs
CACOUB L, AASLD 2017, Abs. 78
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Systematic literature review
- Random-effect model meta-analyses
- Strength of evidence was evaluated using the GRADE system
Results
- Data were extracted from a total of 48 identified studies
- SVR was associated with:
- reduced extrahepatic mortality (vs no SVR, OR = 0.44 [95% CI = 0.28-0.67])
- higher complete remissions in patients with cryoglobulinemia vasculitis (OR = 20.76 [6.73-64.05])
- higher objective response in malignant B-cell lymphoproliferative diseases (OR = 6.49 [2.02-20.85])
- reduced insulin resistance at follow-up (OR = 0.42 [0.33-0.53])
- a significant protective effect on the incidence of diabetes (OR = 0.34 [0.21-0.56])
Limitations
- Lack of randomised data comparing SVR versus non-SVR patients for the relevant extrahepatic indications attenuated these analyses.
