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BROWSE SLIDES

Objective

• Incidence of deaths in DAA-treated patients with decompensated cirrhosis (Child-Pugh B or C) from LDV/SOF and SOF/VEL studies (SOLAR-1, SOLAR-2, ASTRAL-4, N = 463)
• Comparison with the expected incidence in un-treated patients (survival model from liver transplant waitlist in the pre-DAA era: 2 cohorts, one for model development, one for model validation)

Observed versus expected deaths in DAA-treated patients

• 54 deaths expected from survival mode
• 25 deaths observed over 1 year

Standardized mortality ratio

Observed versus expected deaths in DAA-treated patients
Observed deaths from W12 vs expected re-calculated from W12 data update

Conclusions

• Decompensated HCV cirrhosis patients treated with LDV/SOF or SOF/VEL experienced significantly fewer deaths than predicted by the survival model
  • The difference became significant in less than 120 days
  • By the end of the first year, the risk was reduced by 54%
• When the survival model was re-applied with week 12 updated data, observed and expected mortality matched, suggesting
  • Re-compensation following DAA therapy
  • SVR on DAA therapy translates in mortality benefit
  • A further validation of the survival model